Proven Research
A Proven, Research-Backed Constipation Relief Formula
Modern research on traditional herbs commonly used in constipation formulas, particularly Angelica Root (Dang Gui), Thorowax Root (Chai Hu), Cimicifugae Rhizoma (Sheng Ma), and Prepared Licorice Root (Zhi Gan Cao), has explored their effects on intestinal motility, bowel regularity, gastrointestinal function, and digestive balance. A meta-analysis of randomized controlled trials published in Evidence-Based Complementary and Alternative Medicine evaluated a traditional Chinese herbal formula containing Chai Hu, Sheng Ma, Zhi Gan Cao, and Dang Gui in adults with functional constipation and reported improvements in bowel movement frequency and constipation-related outcomes.
Additional research published in the Journal of Ethnopharmacology has examined Angelica sinensis (Dang Gui) and ligustilide, one of its major bioactive constituents, for functional constipation, including effects related to intestinal motility and colonic mucus secretion. A systematic review of traditional herbal formulas for constipation-predominant digestive patterns has also examined formulas containing herbs such as Bupleurum (Chai Hu), Angelica (Dang Gui), and Licorice (Gan Cao), with research exploring bowel movements, intestinal peristalsis, abdominal fullness, and gastrointestinal function.
From a Traditional Chinese Medicine perspective, constipation may develop when Heat and dryness affect the intestines, Qi becomes stagnant, or the normal movement of the Large Intestine is impaired. Herbs within this formula are traditionally combined to promote the movement of Qi, address intestinal dryness and stagnation, relieve abdominal fullness, and support regular bowel elimination.
Research References
Herbal Formula Modified Buzhong-Yiqi-Tang for Functional Constipation in Adults: A Meta-Analysis of Randomized Controlled Trials (Evidence-Based Complementary and Alternative Medicine)
https://pmc.ncbi.nlm.nih.gov/articles/PMC5820555/
Ligustilide Improves Functional Constipation by Non-Covalently Activating TRPA1 in Colon Tissue (Journal of Ethnopharmacology)
https://pubmed.ncbi.nlm.nih.gov/39489358/
Herbal Remedies for Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review of Randomized Controlled Trials
https://pmc.ncbi.nlm.nih.gov/articles/PMC10574070/